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Cell therapy means using cells with therapeutic goals. These cells can be used locally or systemically in tissue or organ compromised. The cells used vary with respect to their state of maturation and differentiation. Cell therapy successful with CT have emerged in recent years and demand for new therapies has brought hopes for the treatment of various diseases.
The development of cell therapies begins with basic research to understand the mechanisms involved in maintaining the undifferentiated state of CT. The second step includes the establishment of lines of CT deposited in banks of TC which are responsible for safekeeping and distribution of these strains. The third step is the production of stem cells on a large scale for use in clinical trials. The fourth stage involves the pre-clinical studies and clinical trials.
The proposal to establish the National Institute of Science and Technology in Cellular Therapy (INCTC) moves in this direction. The INCTC intends to develop a program of basic and clinical research, which is distributing the four stages described.
This challenge can only be overcome with the convergence of efforts of groups that already have experience in this area and now, integrated, can focus their energies and advancing the studies in the field of cell therapy and put the country on an equal footing with the countries further developed this theme.

The INCTC combines the experience of eight years of the Center for Cellular Therapy (USP / Ribeirao Preto), which is one of the CEPIDS FAPESP, and four more groups involved in the issue for several years: the group of Lygia Pereira (IB / USP ), Maria Angelica Miglino (FMVZ / USP) of Flávio Meirelles (FZEA / USP) and Stevens Rehen (UFRJ). A fifth group comes as the Center Emerging Supported (National Primate Center of Bethlehem-PA). This group of researchers have proven experience and complement that fully justifies the premise of networking within the proposal of the National Institutes.

The work plan proposed for the INCTC has three main components: the program of scientific research, educational activities in the broad sense and program of knowledge transfer and innovation to public entities or private.

In these tasks, the INCTC part of the previous experience of CTC-FAPESP connected to the Faculty of Medicine of Ribeirao Preto, USP and that, until recently, was coordinated by Marco Antonio Zago.

The scientific program includes 30 subprojects articulated that, in summary, are: isolate, characterize, understand, cultivate, amplify, tested in animal models and clinical use stem cells obtained from multiple sources of both animals and humans.


The aim is the development of intense activity of transferring knowledge to the company involving the general public, teachers of basic education and their students. Aims to expand the activities that are already made by CTC-Cepid, extending them to the locations of the laboratories involved (Sao Paulo, Pirassununga, Rio de Janeiro and Bethlehem) and proposing new activities with greater coverage. We propose the increase in scale of these initiatives through specialization courses via the Internet, using the platform TIDIA, as part of the Virtual University of São Paulo State (UNIVESP), which may be extended to all over Brazil. We also want to mount courses postgraduate strictest and latu, both for scientific training and for the training of advisers of science.

Finally, regarding the activities of innovation, we intend to broaden the experience of CTC-Cepid that of successfully deployed an incubator for companies within the entity's headquarters (CRH-HCFMRP-USP), with aims to support entrepreneurs in the fields of biotechnology and biomedicine among others. This incubator (INBio) was formed in 2002 and in 2006 joined the SUPERA (incubator of technology-based companies of Ribeirao Preto).





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